Associated with great orchestras, such as Philharmonia Orchestra London, Royal Philharmonic Orchestra London, Orchestre National de France, Belgian National Orchestra, Staatsorchester Stuttgart, St. Petersburg Philharmonic Orchestra, Moscow Philharmonic Orchestra, Large Radio & TV Symphony Orchestra of USSR, Symphony Orchestra of Ministry of Culture of USSR, Mariinsky Theatre Symphony Orchestra St. Petersburg, Presidential Symphony Orchestra Ankara and many other prominent orchestras.

Vakhtang Matchavariani received his musical education at Tbilisi Central Music School and the Tbilisi State Conservatory, initially as a pianist. Later he studied conducting at Tbilisi State Conservatory with Odisey Dimitiriadi, with Gennadi Rozhdestvensky at the Moscow State Conservatory, and finally with Karl Österreicher, at the Vienna Music Academy. During his studies in Viena, Maestro Lorin Maazel wrote about him: " ...An audition was arranged where Mr. Matchavariani conducted the Vienna Philharmonic Orchestra. From what I could ascertain in the short time given Mr. Matchavariani, he has a conducting gift and he showed solid musicianship." Vakhtang Matchavariani has been associated with a number of the world renowned opera houses throughout the world, including seven-year tenure at Mariinsky Theatre in St. Petersburg. He has been a guest conductor at the Scottish Opera in Glasgow, and has been touring with performances. V. Matchavariani has worked with the Bolshoi Theatre in Moscow opera houses in Germany France, Switzerland, Russia, Latvia, Georgia. He has also performed in Verona and conducted operas in a concert version in Spain.